Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions between Non-Coding RNAs in Cancer Cells

Abstract excerpt

<h4>ABSTRACT</h4> Long non-coding RNAs (lncRNAs) represent a vast and functionally diverse class of RNA molecules, with over 100,000 predicted in the human genome. Although lncRNAs are less conserved across species compared to protein-coding genes, they play critical roles in gene regulation, chromatin interactions, and cancer progression. Their involvement in cancer make them promising therapeutic targets. CRISP...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Gene Editing
• Multiple Myeloma
• Oncogenes
• RNA, Guide, CRISPR-Cas Systems
• RNA regulation and disease

Identifiers and source

Literature Corpus work

cbfc628d-5915-540b-9b64-0ccb297b42cc

DOI

10.1101/2024.11.05.622038