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Exploring synthetic lethality in cancer therapy: CRISPR-Cas9 technology offers new hope

13 Jun 2025

Abstract excerpt

Synthetic lethality (SL) is a breakthrough concept in cancer therapy that describes a scenario in which the simultaneous inactivation of two genes leads to cell death, whereas inactivation of either gene alone does not. The rise of clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated nuclease 9 (Cas9) technology has provided a new tool for exploring this phenomenon, enabling genome...

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PMID: 40516634
DOI: 10.1016/j.bbcan.2025.189370

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