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Article

Application of CRISPR-Cas9 for Long Noncoding RNA Genes in Cancer Research

26 Jul 2018

Abstract excerpt

Long noncoding RNAs (LncRNA), a class of transcripts with lengths >200 nt, play a master role in the regulation of cancer pathogenesis. Recently, the CRISPR-Cas9 system has been explored as a revolutionary genome editing tool for molecular biology. Growing evidence shows that LncRNAs can be targeted by the CRISPR-Cas9 system used for evaluating its function. Thus, the CRISPR-Cas9 systems provide a novel...

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PMID: 30045635
DOI: 10.1089/hum.2018.063

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