Article

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosa

2021-10-11

Abstract excerpt

The P23H mutation in rhodopsin (Rho), the visual pigment protein in rod photoreceptor neurons, is the most common genetic cause of autosomal dominant retinitis pigmentosa (adRP), a retinal disease that causes blindness. Despite multiple studies in animal models, the subcellular details of the fate of misfolded mutant Rho in rod photoreceptors have not been completely defined. We generated a new mouse model of adRP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbfaf6f9-13e5-55e1-9417-f45b3e0dcee9
DOI: 10.1101/2021.10.11.463949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosaDOI 10.1101/2021.10.11.463949Read

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.Semantic proximity Read

Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.Semantic proximity Read

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa.Semantic proximity Read

Endoplasmic reticulum stress and rhodopsin accumulation in an organoid model of Retinitis Pigmentosa carrying a RHO pathogenic variantSemantic proximity Read

Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosa.Semantic proximity Read

Loss of αA or αB-Crystallin Accelerates Photoreceptor Cell Death in a Mouse Model of P23H Autosomal Dominant Retinitis Pigmentosa.Semantic proximity Read

P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis.Semantic proximity Read

Mutant rhodopsin transgene expression on a null background.Semantic proximity Read

ER stress in retinal degeneration in S334ter Rho rats.Semantic proximity Read

Rhodopsin mutant P23H destabilizes rod photoreceptor disk membranes.Semantic proximity Read

Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategiesSemantic proximity Read

Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa.Semantic proximity Read