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Article

Rhodopsin mutant P23H destabilizes rod photoreceptor disk membranes.

PloS one - 1 Jan 2012

Haeri Mohammad, Knox Barry E

Abstract excerpt

Mutations in rhodopsin cause retinitis pigmentosa in humans and retinal degeneration in a multitude of other animals. We utilized high-resolution live imaging of the large rod photoreceptors from transgenic frogs (Xenopus) to compare the properties of fluorescently tagged rhodopsin, Rho-EGFP, and Rho(P23H)-EGFP. The mutant was abnormally distributed both in the inner and outer segments (OS), accumulating in the...

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Source

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Identifiers

PMID: 22276148
DOI: 10.1371/journal.pone.0030101
PMCID: PMC3261860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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