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Article

ER stress in retinal degeneration in S334ter Rho rats.

PloS one - 1 Jan 2012

Shinde Vishal M, Sizova Olga S, Lin Jonathan H, LaVail Matthew M, Gorbatyuk Marina S

Abstract excerpt

The S334ter rhodopsin (Rho) rat (line 4) bears the rhodopsin gene with an early termination codon at residue 334 that is a model for several such mutations found in human patients with autosomal dominant retinitis pigmentosa (ADRP). The Unfolded Protein Response (UPR) is implicated in the pathophysiology of several retinal disorders including ADRP in P23H Rho rats. The aim of this study was to examine the onset...

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Source

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Identifiers

PMID: 22432009
DOI: 10.1371/journal.pone.0033266
PMCID: PMC3303830

Genes

AIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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