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Article

Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.

Investigative ophthalmology & visual science - 28 Dec 2011

Price Brandee A, Sandoval Ivette M, Chan Fung, Simons David L, Wu Samuel M, Wensel Theodore G, Wilson John H

Abstract excerpt

PURPOSE: To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at low levels to avoid rapid retinal degeneration, and with a readily visible tag to make it easy...

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Identifiers

PMID: 22110080
DOI: 10.1167/iovs.11-8654
PMCID: PMC3341127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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