Article
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
Frontiers in immunology - 1 Jan 2020
Martinez-Usatorre Amaia, Carmona Santiago J, Godfroid Céline, Yacoub Maroun Céline, Labiano Sara, Romero Pedro
Abstract excerpt
In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specific tumor-infiltrating CD8 T lymphocytes (CD8 TILs). However, these molecules are highly expressed by terminally differentiated exhausted CD8 T cells (Tex) that...
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