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Association between obesity, brain atrophy and accelerated brain aging and their genetic mechanisms

2022-12-30

Abstract excerpt

<h4>Objective</h4> To investigate the causal relationship and the underlying biological mechanisms between body mass index (BMI) and grey matter volume (GMV). <h4>Methods</h4> We applied Mendelian randomization analyses utilizing 33,6514 individuals from the UK Biobank cohort to establish the causal relationship between BMI and GMV. We also quantified obesity-related accelerated brain aging using an XGBoost predic...

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Literature Corpus work
cbf571fb-f772-534d-9777-a18ae851c866
DOI
10.1101/2022.12.30.22284052
Open publication

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Association between obesity, brain atrophy and accelerated brain aging and their genetic mechanismsDOI 10.1101/2022.12.30.22284052
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