Article

A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics

2023-03-29

Abstract excerpt

Genome-wide association studies (GWAS) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While methods have been proposed to characterize pleiotropic components across groups of phenotypes, scaling these approaches to ultra large-scale biobanks has been challenging. Here, we propose FactorGo, a scalable variational factor analysis model to identify and characte...

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Literature Corpus work: cbf35c48-d2e5-51f9-a977-c66ad23638e3
DOI: 10.1101/2023.03.27.23287801

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