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Article

Pleiotropic mapping and annotation selection in genome-wide association studies with penalized Gaussian mixture models.

Bioinformatics (Oxford, England) - 15 Aug 2018

Zeng Ping, Hao Xingjie, Zhou Xiang

Abstract excerpt

Motivation: Genome-wide association studies (GWASs) have identified many genetic loci associated with complex traits. A substantial fraction of these identified loci is associated with multiple traits-a phenomena known as pleiotropy. Identification of pleiotropic associations can help characterize the genetic relationship among complex traits and can facilitate our understanding of disease etiology. Effective...

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PMID: 29635306
DOI: 10.1093/bioinformatics/bty204
PMCID: PMC6084565

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