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Article

Construction and In Vitro Properties of HIV-1 Mutants with Deletions in "Nonessential" Genes

1994-04-01

Abstract excerpt

Auxiliary genes that are not essential for viral replication in cell culture are found in all known lentiviruses. The "nonessential" auxiliary genes of HIV-1 are vif, vpr, vpu , and nef . Sequences within the upstream region of U3 in the LTR are also not required for virus replication in cell culture. We constructed a panel of 23 mutants with single and combination deletions in these regions in the wild-type HIV-1...

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Identifiers and source

Literature Corpus work
cbeb3e03-416c-5620-b5f7-cae78afd3988
DOI
10.1089/aid.1994.10.343
Open publication

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Construction and In Vitro Properties of HIV-1 Mutants with Deletions in "Nonessential" GenesDOI 10.1089/aid.1994.10.343
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