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Article

Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques.

Journal of virology - 1 Sept 2001

Münch J, Adam N, Finze N, Stolte N, Stahl-Hennig C, Fuchs D, Ten Haaft P, Heeney J L, Kirchhoff F

Abstract excerpt

The nef genes of human immunodeficiency virus and simian immunodeficiency virus (SIV) overlap about 80% of the U3 region of the 3' long terminal repeat (LTR) and contain several essential cis-acting elements (here referred to as the TPI region): a T-rich region, the polypurine tract, and attachment (att) sequences required for integration. We inactivated the TPI region in the nef reading frame of the pathogenic...

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Identifiers

PMID: 11483759
DOI: 10.1128/jvi.75.17.8137-8146.2001
PMCID: PMC115058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques.PMID 11483759Read ↗

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