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Article

Construction and <i>In Vitro</i> Properties of SIV <sub>mac</sub> Mutants with Deletions in "Nonessential" Genes

1 Apr 1994

Abstract excerpt

The so-called "nonessential" genes of primate lentiviruses can be deleted without abrogating the ability of virus to replicate under at least some cell culture conditions. In SIVmac, these genes are vif, vpx, vpr, and nef. Sequences in the upstream region of U3 in the LTR have also been shown to be dispensable for replication in cell culture. We report here the construction and characterization of a panel of 40...

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Identifiers

PMID: 8068413
DOI: 10.1089/aid.1994.10.333

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Construction and <i>In Vitro</i> Properties of SIV <sub>mac</sub> Mutants with Deletions in "Nonessential" GenesPMID 8068413Read ↗

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