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Article

The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo.

Virology - 25 Oct 2005

Münch Jan, Rajan Devi, Rücker Elke, Wildum Steffen, Adam Nadia, Kirchhoff Frank

Abstract excerpt

The LTRs of all primate lentiviruses contain long U3 regions overlapping the nef gene. To assess the relevance of the modulatory U3 region for HIV-1 replication, we inactivated the T-rich region, the Polypurine tract and attachment (att) sequences in nef by silent mutations and inserted intact cis-regulatory elements just upstream of the core enhancer. These modifications severely truncated the U3 region and...

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Share to nef Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 16102792
DOI: 10.1016/j.virol.2005.07.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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