Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation.

doi:10.1128/JVI.66.11.6587-6600.1992

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Article

Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation.

Journal of virology - 1 Nov 1992

Li Y, Hui H, Burgess C J, Price R W, Sharp P M, Hahn B H, Shaw G M

Abstract excerpt

Previous studies of the genetic and biologic characteristics of human immunodeficiency virus type 1 (HIV-1) have by necessity used tissue culture-derived virus. We recently reported the molecular cloning of four full-length HIV-1 genomes directly from uncultured human brain tissue (Y. Li, J. C. Kappes, J. A. Conway, R. W. Price, G. M. Shaw, and B. H. Hahn, J. Virol. 65:3973-3985, 1991). In this report, we...

Topics

AIDS Dementia Complex
Adult
Amino Acid Sequence
Base Sequence
Brain
Cells, Cultured
Cloning, Molecular
Defective Viruses
Frameshift Mutation
Genes, Viral
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Genome, Viral

Genotype

HIV-1

Humans

Leukocytes

Macrophages

Source

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Identifiers

PMID: 1404605
DOI: 10.1128/JVI.66.11.6587-6600.1992
PMCID: PMC240154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404605-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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