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Article

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Jun 2010

Fukumori Akio, Fluhrer Regina, Steiner Harald, Haass Christian

Abstract excerpt

Presenilin (PS1 or PS2) is the catalytic component of the gamma-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid beta-peptide. PS is cleaved during complex assembly into its characteristic N- and C-terminal fragments. Both fragments are integral components of physiologically active gamma-secretase and harbor the two critical...

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Identifiers

PMID: 20534834
DOI: 10.1523/JNEUROSCI.1443-10.2010
PMCID: PMC6632680

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Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.PMID 20534834Read ↗

Presenilin endoproteolysis is an intramolecular cleavage.Semantic proximity Read ↗

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Semantic proximity Read ↗

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.Semantic proximity Read ↗

Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.Semantic proximity Read ↗

Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.Semantic proximity Read ↗

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.Semantic proximity Read ↗

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.Semantic proximity Read ↗

Identification of the role of presenilins beyond Alzheimer's disease.Semantic proximity Read ↗

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Semantic proximity Read ↗

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.Semantic proximity Read ↗

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.Semantic proximity Read ↗

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