Article

Flucloxacillin protein binding leads to the presentation of novel MHC peptides

2019-01-01

Abstract excerpt

Flucloxacillin is a β-lactam antibiotic associated with a high incidence of idiosyncratic drug-induced liver reactions. Although expression of HLA-B*57:01 increases susceptibility, little is known of the pathological mechanisms involved in the induction of the clinical phenotype. Off-target protein modification is suspected to drive the reaction, either through non-immune mediated pathways, through the modificatio...

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Literature Corpus work: cbb0a7e6-cd7b-5d48-b596-7583d6989af9
DOI: 10.17638/03066050

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