Article
Plasma Protein Binding Structure–Activity Relationships Related to the N-Terminus of Daptomycin
1 Feb 2017
Abstract excerpt
Daptomycin is a lipopeptide antibiotic that is highly bound to plasma proteins. To date, the plasma components and structure-activity relationships responsible for the plasma protein binding profile of daptomycin remain uncharacterized. In the present study we have employed a surface plasmon resonance assay together with molecular docking techniques to investigate the plasma protein binding structure-activity...
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