Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.

doi:10.1111/j.1528-1157.1998.tb01679.x

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Article

Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.

Epilepsia - 1 Jan 1998

Leeder J S

Abstract excerpt

Hypersensitivity reactions to the aromatic antiepileptic drugs (AEDs) phenytoin (PHT) and carbamazepine (CBZ) appear to have an immune etiology. Current models of drug hypersensitivity center around the concept of drug bioactivation to reactive metabolites that irreversibly modify cellular protei...

Topics

Anticonvulsants
Biotransformation
Carbamazepine
Cytochrome P-450 Enzyme System
Drug Hypersensitivity
Epilepsy
Genotype
Humans
Liver
Models, Immunological
Phenytoin
Polymorphism, Genetic

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