Article

Definition of antigenic determinants in drug hypersensitive patients : an integrated clinical, chemical and cellular approach to quantify and characterize the drug signals presented to T-Lymphocytes

2014-01-01

Abstract excerpt

Idiosyncratic drug hypersensitivity remains a major challenge as it causes high morbidity and mortality. This is complicated by the multiple risk factors implicated and the inability to predict these reactions during the early stages of drug development. Thus, this study attempted to delineate the molecular pathomechanism(s) involved in sulfamethoxazole (SMX) hypersensitivity. The reactive metabolite, nitroso-SMX...

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Literature Corpus work: 99bfcb8c-27e9-5a46-9462-fd18e1f769b9
DOI: 10.17638/00018733

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