Article

Questioning the role of selected somatic <i>PIK3C2B</i> mutations in squamous non-small cell lung cancer oncogenesis

2017-07-17

Abstract excerpt

PI3K signaling is frequently dysregulated in NSCLC-SQCC. In contrast to well characterized components of the PI3K signaling network contributing to the formation of SQCC, potential oncogenic effects of alterations in PIK3C2B are poorly understood. Here, a large cohort (n=362) of NSCLC-SQCC was selectively screened for four reported somatic mutations in PIK3C2B via Sanger sequencing. In addition, two mutations le...

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Literature Corpus work: cbaa9679-d556-5bda-81eb-b9df0c7c79e5
DOI: 10.1101/164749

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