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Article

Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis.

PloS one - 1 Jan 2017

Kind Marcus, Klukowska-Rötzler Jolanta, Berezowska Sabina, Arcaro Alexandre, Charles Roch-Philippe

Abstract excerpt

PI3K signaling is frequently dysregulated in NSCLC-SQCC. In contrast to well characterized components of the PI3K signaling network contributing to the formation of SQCC, potential oncogenic effects of alterations in PIK3C2B are poorly understood. Here, a large cohort (n = 362) of NSCLC-SQCC was selectively screened for four reported somatic mutations in PIK3C2B via Sanger sequencing. In addition, two mutations...

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Identifiers

PMID: 29088297
DOI: 10.1371/journal.pone.0187308
PMCID: PMC5663493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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