Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2023

Daher Sameh, Zer Alona, Tschernichovsky Roi, Yacobi Rinat, Barshack Iris, Tsabari Shani, Rottenberg Yakir, Zick Aviad, Gottfried Teodor, Lobachov Anastasiya, Marom Edith M, Urban Damien, Saad Akram, Gantz-Sorotsky Hadas, Onn Amir, Bar Jair

Abstract excerpt

OBJECTIVES: The identification and targeting of actionable genomic alterations (AGA) have revolutionized the treatment of cancer in general and mostly for non-small cell lung cancer (NSCLC). We investigated whether in NSCLC patients PIK3CA mutations are actionable. MATERIALS AND METHODS: Chart review was performed of advanced NSCLC patients. PIK3CA mutated patients were analyzed as two groups: Group A: without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Carcinoma, Squamous Cell

Share to Catalytic Domain

Share to Class I Phosphatidylinositol 3-Kinases

Share to Lung Neoplasms

Share to Mutation

Source

Identifiers

PMID: 36898331
DOI: 10.1016/j.lungcan.2023.02.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced non-small cell lung cancer.PMID 36898331Read ↗

[Clinicopathological characteristics of lung adenocarcinoma with PIK3CA mutation].Semantic proximity Read ↗

PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.Semantic proximity Read ↗

The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments.Semantic proximity Read ↗

PIK3CA Mutations and Co-Mutations in Operated Non-Small Cell Lung CarcinomaSemantic proximity Read ↗

PIK3CA gene aberrancy and role in targeted therapy of solid malignancies.Semantic proximity Read ↗

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours.Semantic proximity Read ↗

Mutation and prognostic analyses of PIK3CA in patients with completely resected lung adenocarcinoma.Semantic proximity Read ↗

Clinical Significance of PIK3CA Gene in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The mutational profiles and corresponding therapeutic implications of PI3K mutations in cancer.Semantic proximity Read ↗

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.Semantic proximity Read ↗

Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases.Semantic proximity Read ↗

PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.