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Article

Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2012

Rekhtman Natasha, Paik Paul K, Arcila Maria E, Tafe Laura J, Oxnard Geoffrey R, Moreira Andre L, Travis William D, Zakowski Maureen F, Kris Mark G, Ladanyi Marc

Abstract excerpt

PURPOSE: There is persistent controversy as to whether EGFR and KRAS mutations occur in pulmonary squamous cell carcinoma (SQCC). We hypothesized that the reported variability may reflect difficulties in the pathologic distinction of true SQCC from adenosquamous carcinoma (AD-SQC) and poorly diff...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22228640
DOI: 10.1158/1078-0432.CCR-11-2109
PMCID: PMC3487403

Genes

EGFR
KRAS
AKT1
BRAF
ERBB2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22228640-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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