Article

Cell type-specific weighting-factors to solve solid organs-specific limitations of single cell RNA-sequencing

2020-07-06

Abstract excerpt

While single-cell RNA-sequencing (scRNA-seq) is a popular method to analyze gene expression and cellular composition at single-cell resolution, it harbors shortcomings: The failure to account for cell-to-cell variations of transcriptome-size (i.e., the total number of transcripts per cell) and also cell dissociation/processing-induced cryptic gene expression. This is particularly a problem when analyzing highly he...

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Literature Corpus work: 3a235e94-3cad-5cb5-9d7b-ef1d72bc8c2e
DOI: 10.1101/2020.07.05.188276

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