Article

Nanomedicines targeting signaling of protease-activated receptor 2 in organelles provide sustained analgesia

2024-09-14

Abstract excerpt

Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of GPCR signaling in organelles are uncertain due to the challenges of measuring organelle-specific signals and of selectively antagonizing receptors in intracellular compartments. Herein, genetically-encoded biosensors targeted to subcellular compartments were used to analyze organelle-specific signaling...

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Literature Corpus work: cb9764d5-1032-5c6a-9586-ac7b9d9ce456
DOI: 10.1101/2024.09.10.612022

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