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Article

The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2.

PloS one - 1 Jan 2011

Adams Mark N, Christensen Melinda E, He Yaowu, Waterhouse Nigel J, Hooper John D

Abstract excerpt

Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitization by internalisation and degradation. We have explored the role of palmitoylation, the post-translational addition of palmitate, in PAR2 signalling, trafficking, cell...

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Identifiers

PMID: 22140500
DOI: 10.1371/journal.pone.0028018
PMCID: PMC3226677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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