WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

doi:10.1073/pnas.1713625114

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Article

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2017

Kannan Meghna, Bayam Efil, Wagner Christel, Rinaldi Bruno, Kretz Perrine F, Tilly Peggy, Roos Marna, McGillewie Lara, Bär Séverine, Minocha Shilpi, Chevalier Claire, Po Chrystelle, Chelly Jamel, Mandel Jean-Louis, Borgatti Renato, Piton Amélie, Kinnear Craig, Loos Ben, Adams David J, Hérault Yann, Collins Stephan C, Friant Sylvie, Godin Juliette D, Yalcin Binnaz

Abstract excerpt

The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal morphology when inactivated in mice. Remarkably, all seven genes showed corpus callosum defects, including thicker (Atg16l1, Coro1c, Dmxl2, and Herc1), thinner (Kif21b and Wdr89), or absent corpus...

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PMID: 29078390
DOI: 10.1073/pnas.1713625114
PMCID: PMC5676932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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