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Article

Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.

Autophagy - 1 Jan 2000

Simonsen Anne, Cumming Robert C, Finley Kim D

Abstract excerpt

Defects in pathways that direct cellular components to the lysosome for degradation are often linked with a decrease in viability and with progressive disorders. Previously we had shown that blue cheese (bchs: Drosophila homologue of human Alfy) mutations lead to reduced longevity and the accumulation of ubiquitinated neural aggregates. A genetic modifier screen based on overexpression of Bchs in the eye was used...

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PMID: 17617737
DOI: 10.4161/auto.4604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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