Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.

doi:10.1242/dmm.022244

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Article

Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.

Disease models & mechanisms - 1 Apr 2016

Sivachenko Anna, Gordon Hannah B, Kimball Suzanne S, Gavin Erin J, Bonkowsky Joshua L, Letsou Anthea

Abstract excerpt

Debilitating neurodegenerative conditions with metabolic origins affect millions of individuals worldwide. Still, for most of these neurometabolic disorders there are neither cures nor disease-modifying therapies, and novel animal models are needed for elucidation of disease pathology and identification of potential therapeutic agents. To date, metabolic neurodegenerative disease has been modeled in animals with...

Topics

Adrenoleukodystrophy
Animals
Base Sequence
Cell Death
Cell Membrane
Central Nervous System
Coenzyme A Ligases
Disease Models, Animal
Drosophila Proteins
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Duplication

Gene Knockout Techniques

Humans

Lipids

Mutation

Nerve Degeneration

Phenotype

Source

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Identifiers

PMID: 26893370
DOI: 10.1242/dmm.022244
PMCID: PMC4852500

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