Article
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2003
Finley Kim D, Edeen Philip T, Cumming Robert C, Mardahl-Dumesnil Michelle D, Taylor Barbara J, Rodriguez Maria H, Hwang Calvin E, Benedetti Michael, McKeown Michael
Abstract excerpt
A common feature of many human neurodegenerative diseases is the accumulation of insoluble ubiquitin-containing protein aggregates in the CNS. Although Drosophila has been helpful in understanding several human neurodegenerative disorders, a loss-of-function mutation has not been identified that leads to insoluble CNS protein aggregates. The study of Drosophila mutations may identify unique components that are...
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