Article
Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry.
Blood - 3 Dec 2020
Freato Nadia, Ebberink Eduard H T M, van Galen Josse, Fribourg Caroline, Boon-Spijker Mariëtte, van Alphen Floris P J, Meijer Alexander B, van den Biggelaar Maartje, Mertens Koen
Abstract excerpt
The assembly of the enzyme-activated factor IX (FIXa) with its cofactor, activated factor VIII (FVIIIa) is a crucial event in the coagulation cascade. The absence or dysfunction of either enzyme or cofactor severely compromises hemostasis and causes hemophilia. FIXa is a notoriously inefficient enzyme that needs FVIIIa to drive its hemostatic potential, by a mechanism that has remained largely elusive to date. In...
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