Article
The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin Cross-linking.
The Journal of biological chemistry - 8 May 2015
Souri Masayoshi, Osaki Tsukasa, Ichinose Akitada
Abstract excerpt
Covalent cross-linking of fibrin chains is required for stable blood clot formation, which is catalyzed by coagulation factor XIII (FXIII), a proenzyme of plasma transglutaminase consisting of catalytic A (FXIII-A) and non-catalytic B subunits (FXIII-B). Herein, we demonstrate that FXIII-B accelerates fibrin cross-linking. Depletion of FXIII-B from normal plasma supplemented with a physiological level of...
Topics
- Blood Coagulation
- Catalytic Domain
- Coagulants
- Cross-Linking Reagents
- Crystallography, X-Ray
- Factor XIII
- Fibrin
- Fibrinogen
- Fibrinolysin
- Humans
- Peptides
- Phenotype
- Tandem Mass Spectrometry
- Thrombin
- Transglutaminases