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A Late-Fusion Multilayer Perceptron and Logistic Regression Classifier Identifies a SETDB1-Linked Dual-Vulnerability Niche in Non-BRCA Pancreatic Ductal Adenocarcinoma

2026-06-30

Abstract excerpt

<title>Abstract</title> <p>Pancreatic ductal adenocarcinoma (PDAC) remains difficult to treat. PARP inhibitors such as olaparib benefit mainly patients with homologous-recombination defects identified through BRCA testing, but most PDAC patients fall outside this group, and resistance often involves backup DNA repair and epigenetic regulation. SETDB1, an H3K9 methyltransferase linked to chromatin silencing, may s...

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Literature Corpus work: cec14ad0-213d-562e-bb79-f92554fb7831
DOI: 10.21203/rs.3.rs-10168289/v1

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