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Article

Small molecule modulation of the p75 neurotrophin receptor suppresses age- and genotype-associated neurodegeneration in HIV gp120 transgenic mice.

Experimental neurology - 1 Jan 2021

Xie Youmie, Seawell Jaimie, Boesch Emily, Allen Lauren, Suchy Ashley, Longo Frank M, Meeker Rick B

Abstract excerpt

The persistence of HIV in the central nervous system leads to cognitive deficits in up to 50% of people living with HIV even with systemic suppression by antiretroviral treatment. The interaction of chronic inflammation with age-associated degeneration places these individuals at increased risk of accelerated aging and other neurodegenerative diseases and no treatments are available that effectively halt these...

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Identifiers

PMID: 33007293
DOI: 10.1016/j.expneurol.2020.113489
PMCID: PMC8611764

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