Article
Neuropathology of NFHgp160 transgenic mice expressing HIV-1 env protein in neurons.
Journal of neuropathology and experimental neurology - 1 Jun 2001
Michaud J, Fajardo R, Charron G, Sauvageau A, Berrada F, Ramla D, Dilhuydy H, Robitaille Y, Kessous-Elbaz A
Abstract excerpt
The physiopathology of HIV-1 dementia remains largely hypothetical. Although several sets of evidence point towards an indirect multicellular inflammatory pathway, gp120, one of the HIV-1 env products, was shown to be very cytotoxic for neurons in vitro. To explore a direct pathway in the physiopathology of dementia in AIDS, we developed transgenic mouse models carrying the HIV-1 env proteins gp 120 and gp 41 (gp...
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