Article

Widespread Epistasis between Cancer Driver Mutations and Allele-Specific Copy Number Variations

2025-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Cancer driver mutations alone are often insufficient to fully explain tumorigenesis. We demonstrate that these mutations cooperate with somatic copy number variations (CNVs) in a tissue-specific pattern of genomic epistasis. Analyzing 93,462 tumors, we identified 54 gene-cancer type pairs with significant co-occurrence of somatic mutations and CNVs. Our new Binoculars algorithm, which resolved p...

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Literature Corpus work: cb503463-9423-5d73-8882-47e65a071b9a
DOI: 10.64898/2025.12.11.693698

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