Article

Mutation of mutator genes marks immunotherapy efficacy

2022-07-14

Abstract excerpt

<title>Abstract</title> <p>Genomic instability is a hallmark of most cancers and presumably results from dysfunction of mutator genes. Yet methods to identify the complete catalogue of mutator genes in human and systematic investigations of their roles in cancer are lacking. Here we developed MutaGene to define genes associated with suppression of genomic instability and identified 1534 putative mutator genes bas...

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Literature Corpus work: cb381e67-fb03-57c4-aa25-3dc85367729a
DOI: 10.21203/rs.3.rs-1541499/v1

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