Article

Oncometabolite D-2-hydroxyglutarate - dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia

2022-01-27

Abstract excerpt

<title>Abstract</title> <p>Cancer cachexia is characterized by weight loss and skeletal muscle wasting. Based on the up-regulation of catabolism and down-regulation of anabolism, cachexia-associated metabolites and oncometabolites can accumulate in cancer patients. This study focused on genetic mutations-mediated metabolic reprogramming on cancer cachexia progression by screening for active metabolites and examin...

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Literature Corpus work: cb1edd67-de76-5226-bb1c-348d3150936c
DOI: 10.21203/rs.3.rs-1246702/v1

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