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Biological Roles and Therapeutic Applications of IDH2 Mutations in Human Cancer

26 Apr 2021

Abstract excerpt

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts α-KG to 2-hydroxyglutarate (2-HG), which can competitively inhibit a-KG-dependent enzymes, subsequently induces cell metabolic reprograming, inhibits cell...

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PMID: 33981605
DOI: 10.3389/fonc.2021.644857

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