Article
The roles of IDH1 in tumor metabolism and immunity.
Future oncology (London, England) - 1 Nov 2022
Ni Yingqian, Shen Peibo, Wang Xingchen, Liu He, Luo Huiyuan, Han Xiuzhen
Abstract excerpt
IDH1 is a key metabolic enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle that can convert isocitrate into α-ketoglutarate (α-KG) and generate NADPH. The reduction of IDH1 may affect dioxygenase activity and damage the body's detoxification mechanism. Many studies have shown that IDH1 is closely related to the occurrence and development of tumors, and the changes in IDH1 expression levels or...
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