Article

Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2

2020-01-01

Abstract excerpt

Trypanosoma brucei subspecies cause Human African Trypanosomiasis, which is fatal unless treated. T. brucei Aquaglyceroporin 2 (TbAQP2) is required for the uptake of two of the drugs used clinically, pentamidine and melarsoprol. TbAQP2 mutations or the formation of a chimeric gene with TbAQP3 (TbAQP2X3) cause pentamidine-melarsoprol cross-resistance (PMXR). TbAQP2 is an aquaporin, a type of water permeable pore fo...

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Literature Corpus work: cb177aac-eddc-53b2-96f1-683fc74fb236
DOI: 10.17863/cam.57065

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