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Article

Melarsoprol Resistance in African Trypanosomiasis.

Trends in parasitology - 1 Jun 2018

Fairlamb Alan H, Horn David

Abstract excerpt

Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an issue but these drugs have proven to be both effective and quite durable. Unfortunately, melarsoprol-resistant parasites emerged as early as the 1970s and were widespread by the late 1990s. Resistance was due to mutations affecting an...

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Source

Identifiers

PMID: 29705579
DOI: 10.1016/j.pt.2018.04.002

Genes

AQP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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