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Article

Insights from aquaporin structures into drug-resistant sleeping sickness.

eLife - 14 Jan 2026

Matusevicius Modestas, Corey Robin A, Gragera Marcos, Yamashita Keitaro, Sprenger Teresa, Ungogo Marzuq, Blaza James N, Castro-Hartmann Pablo, Chirgadze Dimitri Y, Chaitanya Vedithi Sundeep, Afanasyev Pavel, Melero Roberto, Warshamanage Rangana, Gusach Anastasiia, Carazo José-Maria, Carrington Mark, Blundell Tom, Murshudov Garib N, Stansfeld Phillip J, Sansom Mark S P, De Koning Harry P, Tate Christopher G, Weyand Simone

Abstract excerpt

Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentamidine and melarsoprol through mutations in the aquaglyceroporin TbAQP2 that prevent their uptake. Here, we use cryogenic electron microscopy to determine the structure of TbAQP2...

Topics

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Aquaporin 2
Cryoelectron Microscopy
Drug Resistance
Glycerol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Dynamics Simulation

Trypanocidal Agents

Trypanosoma brucei brucei

Trypanosomiasis, African

Source

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Identifiers

PMID: 41533537
DOI: 10.7554/eLife.107460
PMCID: PMC12803511

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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