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Insights from aquaporin structures into drug-resistant sleeping sickness

2025-05-17

Abstract excerpt

Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentamidine and melarsoprol through mutations in the aquaglyceroporin TbAQP2 that prevent their uptake. Here we use cryogenic electron microscopy to determine the structure of TbAQP2 fr...

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Identifiers and source

Literature Corpus work
5e770078-e26e-56ce-8a04-36c5fe34fc5d
DOI
10.1101/2025.05.15.654314
Open publication

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Insights from aquaporin structures into drug-resistant sleeping sicknessDOI 10.1101/2025.05.15.654314
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