Article

An integrated cardiac microtissue proteome map extends therapeutic remodelling by nanovesicles

2026-05-07

Abstract excerpt

Human cardiac microtissues are a promising model to study cardiac biology and disease, but their application is constrained by therapeutic remodelling strategies and limited knowledge of their functional protein expression profiles. Here, we define the use of human cardiac microtissue (hCMT) model generated by assembling iPSC-derived endothelial cells, cardiac fibroblasts, and cardiomyocytes to model ischemia-repe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: caf0a967-4931-5a33-8dc5-63bb766589a9
DOI: 10.64898/2026.05.03.722552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An integrated cardiac microtissue proteome map extends therapeutic remodelling by nanovesiclesDOI 10.64898/2026.05.03.722552Read

Hypoxia Modulates Nanovesicle Phenotype and Angiogenic Function From Human Pluripotent Stem Cells.Semantic proximity Read

Epicardial extracellular vesicles modulate gene expression following ischemia-reperfusion injury in heart-on-a-chipSemantic proximity Read

Tissue microenvironment dictates the state of human induced pluripotent stem cell-derived endothelial cells of distinct developmental origin in 3D cardiac microtissuesSemantic proximity Read

Enhancing Myocardial Repair with CardioClustersSemantic proximity Read

Naturally aligned cell delivery platform to augment post-infarction neovasculature and ventricular remodelingSemantic proximity Read

Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart.Semantic proximity Read

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cellsSemantic proximity Read

Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressorsSemantic proximity Read

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cellsSemantic proximity Read

Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screeningSemantic proximity Read

ReCardioids: a robust human heart organoid platform to model doxorubicin- and radiotherapy-induced cardiotoxicitySemantic proximity Read

Vascularized Human Cardiac Organoids Reveal Endothelial–Cardiomyocyte Crosstalk and Mechanisms of Carfilzomib-Induced CardiotoxicitySemantic proximity Read