Article

Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressors

2025-10-16

Abstract excerpt

<h4>Aims</h4> Heart failure remains a leading cause of morbidity and mortality worldwide. Suitable in vitro models to accurately replicate the pathological environment in heart failure with reduced and preserved ejection fraction (HFrEF/HFpEF) are limited, hampering mechanistic studies and drug screening. In particular, these models rarely incorporate immune cells, which play a critical role in heart failure. To...

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Literature Corpus work: 55b09b88-9698-5336-a1f2-2c970729372d
DOI: 10.1101/2025.10.16.682827

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