Article

Tissue microenvironment dictates the state of human induced pluripotent stem cell-derived endothelial cells of distinct developmental origin in 3D cardiac microtissues

2022-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Each tissue and organ in the body has its own type of vasculature. Here we demonstrate that organotypic vasculature for the heart can be recreated in a three-dimensional cardiac microtissue (MT) model composed of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs), cardiac fibroblasts (CFs) and endothelial cells (ECs). ECs in cardiac MTs upregulated expression of markers enr...

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Literature Corpus work: 1ee6d2c0-dd74-56ad-a64e-3ce50471f703
DOI: 10.1101/2022.11.22.517426

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