Article

Epicardial extracellular vesicles modulate gene expression following ischemia-reperfusion injury in heart-on-a-chip

2025-08-02

Abstract excerpt

The epicardium is an essential regulator of cardiac development, homeostasis, and injury, yet the composition and impacts of epicardial cell-secreted extracellular vesicles (EVs) remain incompletely understood. Here, we harness an epicardial Biowire platform integrating human stem cell derived epicardial cells with functional myocardium and apply transcriptomics to reveal enriched EV transport in tissues containin...

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Literature Corpus work: 51b793bb-429d-5961-ac86-ee4b740d3256
DOI: 10.1101/2025.07.31.667965

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